TYPE OF COURSE UNIT	Elective Course
LEVEL OF COURSE UNIT	Bachelor's Degree
YEAR OF STUDY	-
SEMESTER	-
NUMBER OF ECTS CREDITS ALLOCATED	2
NAME OF LECTURER(S)	-
LEARNING OUTCOMES OF THE COURSE UNIT	At the end of this course, the students; 1) Knows the basic approaches of pharmaceutical raw material production and their application to drug synthesis.
MODE OF DELIVERY	Face to face
PRE-REQUISITES OF THE COURSE	No
RECOMMENDED OPTIONAL PROGRAMME COMPONENT	None
COURSE DEFINITION	Fundamentals of industrial scale production. Lab scale productions scale up and pilot production systems, unit processes Reactors and their constituents. Material information, weighing, mixing, heating and cooling Filtering and drying (vacuum devices, centrifuges, pumps and dryers) Extraction, distilation, condensation Selection of materials used in pharmaceutical raw material production. Water and energy. Materials used in pharmaceutical raw materials productionMaterials used in the production of pharmaceutical raw materials Drug master file (DMF) content Pharmaceutical raw materials produced in Turkey.
COURSE CONTENTS	WEEK TOPICS 1st Week Fundamentals of industrial scale production 2nd Week Lab scale productions scale up and pilot production systems, unit processes 3rd Week Reactors and their constituents 4th Week Material information 5th Week Weighing, mixing, heating and cooling 6th Week Filtering and drying (vacuum devices, centrifuges, pumps and dryers) 7th Week Extraction, distilation, condensation 8th Week Midterm exam 9th Week Selection of materials used in pharmaceutical raw material production. Water and energy. 10th Week Materials used in pharmaceutical raw materials production 11th Week Materials used in the production of pharmaceutical raw materials (ferrous and non-ferrous materials) 12th Week Drug master file (DMF) content 13th Week Pharmaceutical raw materials produced in Turkey 14th Week Raw material synthesis examples
RECOMENDED OR REQUIRED READING	1. Ergenç, N., Salman S., Salman, A., `Türkiyede Üretilen İlaç Etken Maddeleri? İstanbul, 1992. 2. Shreve R.N.,? Chemical Process Industries?, Mc Graw Hill 1977. 3. Smith J.C., `Unit Operations of Chemical Engineering?, Mc Graw Hill, 2000. 4. Houson, I., Process Understanding: For Scale-Up and Manufacture of Active Ingredients, Wiley-VCH Verlag GmbH & Co.KgaA, 2011. 5. Mehra, V., Pratik Kimya Mühendisliği El Kitabı? TMMOB yayınları, İstanbul 2007. 6. Shioriri, T., Izawa, K., Konoike, T., Pharmaceutical Process Chemistry ?,Wiley-VCH Verlag GmbH & Co. KgaA, 2011. 7. Shukshith K.S, N. Vishal Gupta, Water for Pharmaceutical Use, Int. J. Pharm. Sci. Rev. Res., 36(1), 2016; Article No. 35, 199-204. 8. Christina Galitsky et all, Improving Energy Efficiency in Pharmaceutical Manufacturing Operations, Part II: HVAC, Boilers and Cogeneratio, LBNL-60288 Part II, 2006. 9. Victor Sanchez et all, In-Process Control Methods for the Manufacture of APIs, Pharmaceutical Technology. 10. McCabe, W.L., Smith, J.C., Unit Operations of Chemical Engineering, McGraw Hill, 2000. 11. Groggins, P.H., Unit Processes in Organic Synthesis, McGraw Hill, 1958.
PLANNED LEARNING ACTIVITIES AND TEACHING METHODS	Lecture,Questions/Answers,Problem Solving,Discussion
ASSESSMENT METHODS AND CRITERIA	Quantity Percentage(%) Mid-term 1 40 Total(%) 40 Contribution of In-term Studies to Overall Grade(%) 40 Contribution of Final Examination to Overall Grade(%) 60 Total(%) 100
ECTS WORKLOAD	Activities Number Hours Workload Midterm exam 1 1 1 Preparation for Quiz 0 0 0 Individual or group work 14 1 14 Preparation for Final exam 1 10 10 Course hours 14 2 28 Preparation for Midterm exam 1 5 5 Laboratory (including preparation) 0 0 0 Final exam 1 2 2 Homework 0 0 0 Total Workload 60 Total Workload / 30 2 ECTS Credits of the Course 2
LANGUAGE OF INSTRUCTION	Turkish
WORK PLACEMENT(S)	No