At the end of this course, the students; 1) To be able to understand the structure, properties, classification of bacteria, fungi, viruses and parasites; the relationship between humans and microorganisms, pathogenesis of infectious diseases and the diseases caused by microorganisms. 2) o be informed about the laboratory methods that used for the identification of bacteria, fungi and parasites. 3) o understand the mechanisms of action of chemotherapeutics and the mechanisms of resistance against these chemotherapeutics. 4) o evaluate the clinical cases by means of genetic disordes and to have ability of assessment of diagnostic tests. 5) o be informed about the general principles of cancer therapy which is based on tumor biology and kinetics. 6) o identify the basic mechanisms and morphological findings of cell injury and hemodynamic disorders and to associate them with clinical findings. 7) o identify the basic mechanisms and morphological findings of inflammation, neoplasia, infectious diseases, immune system disorders and to associate them with clinical findings. 8) o learn tumor antigens, cellular and humoral immunity against tumors, immunological diagnosis, cellular and humoral immunotherapy, tumor vaccines and antiangiogenic therapy. 9) To learn the basic steps and clinical importance of metastasis, cell-cell adhesion molecules, degradation of matrix, tumoral angiogenesis, tumor invasion, adhesion to extracellular matrix proteins, invasion to vessels, adhesion to endothelium and extravasation, angiogenesis in metastatic foci, metastaic phenotypes and organ specific metastases. 10) To learn the etiological factors, epidemiology of tumors; the differences between tumors of pediatrics and adults, clinical properties, basic principles of staging, cancer therapy and prognosis. 11) biological systems and the preventive measures from radiation. 12) To be able to describe the basic principles of pharmacology with pharmacokinetic and pharmacodynamic aspects, to explain the pharmaceutical forms and administration routes of drugs, the mechanisms and principle management strategies for drug intoxication. 13) To describe the new drug development strategies and basic pirinciples in autocoid pharmacology,
MODE OF DELIVERY
Face to face
PRE-REQUISITES OF THE COURSE
No
RECOMMENDED OPTIONAL PROGRAMME COMPONENT
The entire curriculum of the academic year
COURSE DEFINITION
This course reviews the basic principles of development of disease and specific immune system responses and pharmacokinetics/pharmacodynamics of the therapeutic agents. This course is carried out with the co-operation of Physiology, Immunology, Biochemistry, Pharmacology, Pathology, Medical Biology, Biophysics, Microbiology and Radiology Departments.
COURSE CONTENTS
In this course, the students will be informed about the basic mechanisms in the development of diseases; structure, general properties, classification of bacteria, fungi, viruses and parasites; the relationship between humans and microorganisms, pathogenesis of infectious diseases and the diseases caused by microorganisms. Also, pharmacokinetics, pharmacodynamics, antimicrobial agents, autacoids, drug-drug interactions, adverse and toxic effects of drugs will be mentioned. Physical, biological, chemical, immunological, genetic and pathological basis of diseases will be mentioned. Approaches about diagnostic/therapeutic methods and disease prevention will also be mentioned in the context of these basis.
RECOMENDED OR REQUIRED READING
1. Kayaalp, S.O. 2012. Akılcıl Tedavi Yönünden Tıbbi Farmakoloji, 13. Basım, Pelikan Yayıncılık, Ankara, Türkiye. 2. Kayaalp, S.O. 2007. Klinik Farmakolojinin Esasları ve Temel Düzenlemeler, 4. Basım, Pelikan Yayıncılık. 3. LaurenceBrunton, Bruce Chabner, BjornKnollman (editörler) 2011. Goodman&Gilman?s The Pharmacological Basis of Therapeutics, 12. Basım, McGraw-Hill, New York, A.B.D. 4. Murray PR. (2018) ''Temel Tıbbi Mikrobiyoloji'', Çeviri Editörleri: Us AD, Başustaoğlu A. Elsevier - Güneş Tıp Kitabevleri. 5. Murray PR, Rosenthal KS, Pfaller MA. ''Tıbbi Mikrobiyoloji, 7. Baskı'', Çeviri Editörleri: Başustaoğlu A, Us AD. Elsevier - Pelikan Yayıncılık Ltd. Şti. 6. Brooks GF, Butel JS, Morse SA. ''Jawetz, Melnick, & Adelberg?s Medical Microbiology, 26th edition'', McGraw-Hill Companies inc., USA. 7. Topçu AW, Söyletir G, Doğanay M. (2008) ?Enfeksiyon Hastalıkları ve Mikrobiyolojisi? Cilt1-2, Nobel Matbaacılık. Türkiye. 8. Roitt I, Brotoff J, Male D (2001) ?Immunology? Sixthedition, MosbyInc, Missouri USA 9. Parslow TG, Stites DP, Terr AI, Imboden JB (2001) ?Medical Immunology? Tenth edition, McGraw-Hill Companies inc., USA 10. Pathologic Basis of Disease; Eds. Cotran R.S., Kumar V.K., Collins T., Sixth Edition, W.B. SaundersCompany, 1999 11. Histology for Pathologist; Ed. Sternberg S. S., First Edition, RavenPress, New York, 1992 12. Biyofizik, Prof. Dr. Ferit Pehlivan, sekizinci baskı, Pelikan Yayınevi Ltd. Şti., Ankara, 2015. 13. John E. Hall; Guyton Tıbbi Fizyoloji, Çevirmen: Berrak Ç. Yeğen, İnci Alican, Zeynep Solakoğlu, 2016, Güneş Tıp Kitabevleri 14. Fox: Human Physiology, Eighth Edition, The McGraw?Hill Companies Inc, 2003. 15. Nussbaum RL, McInnes RR, Willard HF, Thompson MW (2016) Thompson&Thompson genetics in medicine, 8th Edition. Philadelphia: Saunders/Elsevier. 16. Baynes, J. and Dominiczak, M.H. 2009, Medical Biochemistry.Third ed. Elsevier Mosby, New York, USA. 17. Devlin, T.M. 2011.Textbook of Biochemistry with Clinical Correlations. 7th Edition,Wiley-Liss, Inc., New York, USA.
