| TYPE OF COURSE UNIT | Elective Course |
| LEVEL OF COURSE UNIT | Master's Degree With Thesis |
| YEAR OF STUDY | - |
| SEMESTER | - |
| NUMBER OF ECTS CREDITS ALLOCATED | 10 |
| NAME OF LECTURER(S) | Professor Özlem Darcansoy İşeri
|
| LEARNING OUTCOMES OF THE COURSE UNIT |
At the end of this course, the students;
1) Cytotoxic chemotherapeutic agents, their classification, and with their mechanism of action
2) Receptor tyrosine kinase inhibitors, monoclonal antibodies, small molecules, and immunotherapy approaches
3) Recent drug targeting and delivery approaches
4) Recent therapeutic approaches
|
| MODE OF DELIVERY | Face to face |
| PRE-REQUISITES OF THE COURSE | No |
| RECOMMENDED OPTIONAL PROGRAMME COMPONENT | Cancer Molecular Biology, Nanotechnology |
| COURSE DEFINITION | In this course, chemotherapeutic agents and their classification are defined, and mechanisms of action of cytotoxic chemotherapeutic agents, receptor tyrosine kinases, monoclonal antibodies, immunotherapy, and drug targeting and delivery approaches are discussed. Students are required to discuss recent research articles in the area. |
| COURSE CONTENTS | | WEEK | TOPICS |
|---|
| 1st Week | Introduction to Cancer Biology | | 2nd Week | Cytotoxic Chemotherapeutic Agents I: Alkylating Agents | | 3rd Week | Cytotoxic Chemotherapeutic Agents II: Topoisomerase Inhibitors | | 4th Week | Cytotoxic Chemotherapeutic Agents III: Antimetabolites | | 5th Week | Cytotoxic Chemotherapeutic Agents IV: Microtubule Inhibitors | | 6th Week | Epigenetic Modifiers and Proteosome Inhibitors | | 7th Week | Hormones and Hormone Antagonists | | 8th Week | Midterm | | 9th Week | Tyrosine Kinase Inhibitors and Angiogenesis Inhibitors | | 10th Week | Monoclonal Antibodies | | 11th Week | Chemotherapy Strategies and New Approaches | | 12th Week | Discussion on Articles: Drug targeting and Delivery approaches | | 13th Week | Discussion on Articles: Gene Therapy | | 14th Week | Student Presentations and Discussion on Articles: Immunotherapy |
|
| RECOMENDED OR REQUIRED READING | ? Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics (Fourth Edition), Lauren Pecorino, Oxford University Press, 2016.
? The Biology of Cancer (2nd Edition), Robert A. Weinberg, W. W. Norton & Company, 2013.
? Recent articles
|
| PLANNED LEARNING ACTIVITIES AND TEACHING METHODS | Lecture,Presentation,Discussion,Questions/Answers |
| ASSESSMENT METHODS AND CRITERIA | | | Quantity | Percentage(%) |
|---|
| Mid-term | 1 | 25 | | Presentation of Article | 1 | 20 | | Presentation of Case Study | 1 | 10 | | Total(%) | | 55 | | Contribution of In-term Studies to Overall Grade(%) | | 55 | | Contribution of Final Examination to Overall Grade(%) | | 45 | | Total(%) | | 100 |
|
| ECTS WORKLOAD |
| Activities |
Number |
Hours |
Workload |
| Midterm exam | 1 | 3 | 3 | | Preparation for Quiz | | | | | Individual or group work | | | | | Preparation for Final exam | 1 | 40 | 40 | | Course hours | 14 | 3 | 42 | | Preparation for Midterm exam | 1 | 30 | 30 | | Laboratory (including preparation) | | | | | Final exam | 1 | 3 | 3 | | Homework | | | | | Presentation (including preperation) | 1 | 25 | 25 | | Project | 1 | 35 | 35 | | Literature review | 1 | 55 | 55 | | Article Presentation | 1 | 70 | 70 | | Total Workload | | | 303 |
|---|
| Total Workload / 30 | | | 10,1 |
|---|
| ECTS Credits of the Course | | | 10 |
|---|
|
| LANGUAGE OF INSTRUCTION | English |
| WORK PLACEMENT(S) | No |
| | |
