At the end of this course, the students; 1) Know the basic control system theories. 2) Considering as a control system, modeling the physiological system. 3) Evaluate the model results to comprehend the physiological system quantitatively.
MODE OF DELIVERY
Face to face
PRE-REQUISITES OF THE COURSE
No
RECOMMENDED OPTIONAL PROGRAMME COMPONENT
None
COURSE DEFINITION
Modeling, representation and analysis of physiological control systems, using control theory techniques. Applications will be modeling and control problems in cellular and general physiology. The first part of the course will introduce the basic concepts of control systems. The second part of the course will discuss various biological systems, and their natural and driven control mechanisms. It will demonstrate the different properties of the various control systems and show how they interact.
COURSE CONTENTS
WEEK
TOPICS
1st Week
Introduction, Mathematical Modeling, Generalized System properties, Linear Models of physiological systems,
2nd Week
Laplace Transform and Transfer Function, State-space analysis
3rd Week
Static Analysis of Physiological Systems, Determination of steady-state operating point, Regulation of cardiac output,
4th Week
Heart and Systemic Circulation, Regulation of Glucose, Chemical regulation of ventilation,
5th Week
Time Domain analysis of Linear Control Systems, Linearized Respiratory mechanics, open-loop and closed-loop transient responses,
6th Week
Descriptors of impulse and step responses, Other considerations
7th Week
Frequency Domain analysis of Linear Control systems, Steady-state responses, graphical representations (Bode plots, Nichols Charts, Nyquist Plots)
8th Week
Midterm Exam
9th Week
Response of a model of Circulatory control, Frequency response of glucose-insulin regulation
10th Week
Stability analysis, Stability and transient response, root locus plots, Routh-Hurwithz stability criterion, Nyquist criterion,
11th Week
relative stability, Stability analysis of the papillary light reflex, Model of Cheyne-Stokes breathing
12th Week
Introduction to Identification of Physiological Control Systems
13th Week
Term Project representation
14th Week
Term Project representation
RECOMENDED OR REQUIRED READING
Pysiological Control Systems Micheal C.K.Khoo
PLANNED LEARNING ACTIVITIES AND TEACHING METHODS
Lecture,Project,Presentation
ASSESSMENT METHODS AND CRITERIA
Quantity
Percentage(%)
Mid-term
1
30
Assignment
1
10
Quiz
1
10
Project
1
20
Total(%)
70
Contribution of In-term Studies to Overall Grade(%)
70
Contribution of Final Examination to Overall Grade(%)
30
Total(%)
100
ECTS WORKLOAD
Activities
Number
Hours
Workload
Midterm exam
1
72
72
Preparation for Quiz
1
20
20
Individual or group work
Preparation for Final exam
1
24
24
Course hours
14
3
42
Preparation for Midterm exam
1
11
11
Laboratory (including preparation)
0
0
0
Final exam
1
72
72
Homework
1
20
20
Project
1
24
24
Total Workload
285
Total Workload / 30
9,5
ECTS Credits of the Course
10
LANGUAGE OF INSTRUCTION
Turkish
WORK PLACEMENT(S)
No
KEY LEARNING OUTCOMES (KLO) / MATRIX OF LEARNING OUTCOMES (LO)
