TYPE OF COURSE UNIT	Elective Course
LEVEL OF COURSE UNIT	Master's Degree With Thesis
YEAR OF STUDY	-
SEMESTER	-
NUMBER OF ECTS CREDITS ALLOCATED	10
NAME OF LECTURER(S)	Assistant Professor Özge Erdemli
LEARNING OUTCOMES OF THE COURSE UNIT	At the end of this course, the students; 1) Learn the basic principles of protein and gene delivery systems. 2) Gain knowledge about the basic principles of controlled drug delivery systems. 3) Understand the role of micro and nanocarrier systems in the delivery of protein and genes. 4) Learn the targeted delivery systems for peptides and proteins. 5) Gain knowledge about the next generation delivery system for proteins and genes.
MODE OF DELIVERY	Face to face
PRE-REQUISITES OF THE COURSE	No
RECOMMENDED OPTIONAL PROGRAMME COMPONENT	Nanotechnology, Biomolecules, Biomaterials, Biochemistry I
COURSE DEFINITION	This course introduces students to the concept of delivery systems of peptides, proteins, oligonucleotides and genes. Microparticles/nanoparticles for targeted and controlled delivery systems, stimuli responsive delivery systems of proteins and genes and their biomedical applications are discussed. Students are required to discuss recent research articles in the area.
COURSE CONTENTS	WEEK TOPICS 1st Week Course overview 2nd Week Pharmacokinetics of peptide and protein drugs 3rd Week Microparticle-based delivery systems for peptides and proteins 4th Week Nanoparticle-based delivery systems for peptides and proteins 5th Week Targeted delivery systems for peptides and proteins 6th Week Hydrogel-based delivery systems for peptides and proteins 7th Week Stimuli responsive delivery systems of peptides and proteins 8th Week Midterm Exam 9th Week Delivery of genes and oligonucleotides 10th Week Viral vectors for gene delivery 11th Week Non-viral vectors for gene delivery 12th Week Physical/mechanical methods for gene delivery 13th Week Next generation delivery system for proteins and genes 14th Week Students Presentations
RECOMENDED OR REQUIRED READING	Drug Delivery: Principles and Applications, Second Edition, Editors: Binghe Wang, Longoin Hu, Teruna J. Siahaan, John Wiley & Sons, 2016. Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines, Editors: Lene Jorgensen, Hanne Morck Nielsen, John Wiley & Sons, 2009. Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids, Editors: Surendra Nimesh, Ramesh Chandra, Nidhi Gupta, Woodhead Publishing, 2017. Therapeutic Peptides and Proteins Formulation, Processing, and Delivery Systems, Third Edition, CRC Press, 2015. Recent articles
PLANNED LEARNING ACTIVITIES AND TEACHING METHODS	Lecture,Discussion,Questions/Answers,Presentation
ASSESSMENT METHODS AND CRITERIA	Quantity Percentage(%) Mid-term 1 30 Presentation of Article 2 25 Total(%) 55 Contribution of In-term Studies to Overall Grade(%) 55 Contribution of Final Examination to Overall Grade(%) 45 Total(%) 100
ECTS WORKLOAD	Activities Number Hours Workload Midterm exam Preparation for Quiz Individual or group work 14 2 28 Preparation for Final exam 1 100 100 Course hours 13 3 39 Preparation for Midterm exam 1 70 70 Laboratory (including preparation) Final exam 1 3 3 Homework Article Presentation 2 30 60 Total Workload 300 Total Workload / 30 10 ECTS Credits of the Course 10
LANGUAGE OF INSTRUCTION	English
WORK PLACEMENT(S)	No