At the end of this course, the students; 1) Learn basic princples of bioelectricity and biomagnetism. 2) Have an ability for modelling physiological system. 3) Analyzing physiological systems and their models. 4) Learn mathematical calculations and engineering techniques in bioelectricity and biomagnetism fields.
MODE OF DELIVERY
Face to face
PRE-REQUISITES OF THE COURSE
No
RECOMMENDED OPTIONAL PROGRAMME COMPONENT
None
COURSE DEFINITION
Vector Analysis, Electrical Sources and Fields, Introduction to Membrane Biophysics, Action Potentials, Volume Conductor Fields, Electrophysiology of the Heart, Electrocardiography (ECG), electric and magnetic lead fields, Electroencephalography (EEG), Magneto encephalography (MEG). Forward and inverse problem of ECG. The main objective of this course is to provide an overview of the general principles of electric and magnetic fields in biological environments and application of these principles to obtain information from the human body.
COURSE CONTENTS
WEEK
TOPICS
1st Week
Introduction. The review of vectors, gradient, divergence.Electrical fields and mathematical relationships
2nd Week
Cell Membrane Bioelectricity Properties. Transmembrane potantial, ion channels, ion pomps, Donnan equation, Goldman equation
3rd Week
Action Potantial. Strength-duration curve
4th Week
Membrane's Active Behaviour. Voltage clamp method. Hodkin-Huxley model
5th Week
Propagation. Mathematical representation of action potential propagation
6th Week
Bioelectrical Relationship Between Extracellular Fields. Extracellular potentials. Maxwell equation
7th Week
The Electrophysiology of the Heart. Electrical conduction of heart, einthoven vector,basis of electrocardiography(ECG)
8th Week
Midterm Exam
9th Week
ECG. Clinical electrocardiography, ECG measurement methods, forward problem solutions related with ECG.
10th Week
Brain Electrical Field. Potential changes in brain, electroencefalagraphy (EEG), EEG measurement methods and properties
11th Week
Biomagnetic. Magnetostatic equations, magnetic flux density measurement, magnetocardiography (MCG) and magnetoencefalography (MEG)
12th Week
Biomagnetic. Magnetostatic equations, magnetic flux density measurement, magnetocardiography (MCG) and magnetoencefalography (MEG)
13th Week
Measurement of intrinsic properties. Electrical impedance imaging using several applied currents and voltage measurements, magnetic measurement of magnetic susceptibility
14th Week
Measurement of intrinsic properties. Electrical impedance imaging using several applied currents and voltage measurements, magnetic measurement of magnetic susceptibility
RECOMENDED OR REQUIRED READING
(1)R. Plonsey, R. C. Barr, Bioelectricity, 1988, Plenum Press, New York (2)R. M. Gulrajani, Bioelectricity and Biomagnetism, 1998, John Wiley & Sons, Inc. (3)J. Malmivuo, R. Plonsey, Bioelectromagnetism, 1995, Oxford University Pres.